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Related Experiment Videos

Antidepressants for smoking cessation.

J R Hughes1, L F Stead, T Lancaster

  • 1Department of Psychiatry, University of Vermont, 38 Fletcher Place, Burlington, Vermont 05401-1419, USA. john.hughes@uvm.edu

The Cochrane Database of Systematic Reviews
|March 1, 2002
PubMed
Summary
This summary is machine-generated.

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Certain antidepressants, specifically bupropion and nortriptyline, can help individuals quit smoking. Further research is needed to determine if these effects are drug-specific or apply to all antidepressants for smoking cessation.

Area of Science:

  • Pharmacology
  • Addiction Medicine
  • Clinical Trials

Background:

  • Depression can be a symptom of nicotine withdrawal, and smoking cessation may precipitate depression.
  • Nicotine's potential antidepressant effects might maintain smoking behavior in some individuals.
  • Antidepressants may serve as a substitute for nicotine's mood-regulating effects.

Purpose of the Study:

  • To evaluate the efficacy of antidepressant medications in achieving long-term smoking cessation.
  • To review trials involving bupropion, doxepin, fluoxetine, imipramine, moclobemide, nortriptyline, paroxetine, selegiline, sertraline, tryptophan, and venlafaxine.

Main Methods:

  • Systematic review of randomized controlled trials comparing antidepressants to placebo or alternative therapies.
  • Searched Cochrane Tobacco Addiction Group trials register (MEDLINE, EMBASE, SciSearch, PsycLIT) up to September 2001.

Related Experiment Videos

  • Included trials with a minimum of six months follow-up, extracting data on study population, drug therapy, outcomes, and randomization.

    • Main Results:

    • Bupropion and nortriptyline demonstrated increased smoking cessation rates.
    • One trial indicated that combining bupropion with the nicotine patch yielded slightly higher quit rates than the patch alone.
    • Limited trials were available for moclobemide, sertraline, venlafaxine, fluoxetine, and nortriptyline.

    Conclusions:

    • Bupropion and nortriptyline are effective antidepressants for aiding smoking cessation.
    • It remains unclear whether the observed benefits are exclusive to these specific drugs or applicable to all antidepressants.