Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Integrated acidity and rabeprazole pharmacology.

J D Gardner1, C Perdomo, S Sloan

  • 1Science for Organizations Inc., Chatham, NJ 07928, USA. gardnerj@bellatlantic.net

Alimentary Pharmacology & Therapeutics
|March 6, 2002
PubMed
Summary

Rabeprazole effectively reduces gastric and oesophageal acidity in GERD patients. Integrated acidity measurements offer a sensitive method to assess treatment effects and understand GERD pathophysiology.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Irrigation and phosphorous fertilization management to minimize rice grain arsenic content.

Chemosphere·2022
Same author

Inflammatory cardiac fibroblast phenotype underlies chronic alcohol-induced cardiac atrophy and dysfunction.

Life sciences·2020
Same author

Effect of lorcaserin on weight reduction in persons with obstructive sleep apnea (OSA): a combined subgroup analysis from three randomized, controlled clinical trials.

Obesity science & practice·2019
Same author

Effect of lorcaserin in different age groups: a post hoc analysis of patients from the BLOOM, BLOSSOM and BLOOM-DM studies.

Obesity science & practice·2019
Same author

Lorcaserin and metabolic disease: weight-loss dependent and independent effects.

Obesity science & practice·2018
Same author

Persistent spatial structuring of coastal ocean acidification in the California Current System.

Scientific reports·2017

Area of Science:

  • Gastroenterology
  • Pharmacology
  • Clinical Medicine

Background:

  • Integrated gastric and oesophageal acidity quantify acidity over time.
  • Rabeprazole is a proton pump inhibitor for gastro-oesophageal reflux disease (GERD).

Purpose of the Study:

  • To determine rabeprazole's onset, duration, and effect on acidity in GERD patients.
  • Utilize integrated acidity measurements for novel insights.

Main Methods:

  • Recruited GERD patients with specific pH criteria.
  • Measured 24-h gastric and oesophageal pH on days 1 and 7 of rabeprazole (20 mg) dosing.
  • Calculated integrated acidity from time-weighted average hydrogen ion concentrations.

Main Results:

Related Experiment Videos

  • Rabeprazole (20 mg) achieved 89% gastric and 95% oesophageal acidity inhibition at steady-state.
  • First dose showed at least 70% of steady-state inhibition.
  • Onset of action varied (4-7 hours) based on GERD subtype (monophasic/biphasic).
  • Integrated acidity was more sensitive than time pH ≤ 4.

    • Conclusions:

    • Integrated acidity measurements provide quantitative data on GERD pathophysiology.
    • These measurements offer novel insights into the impact of antisecretory agents like rabeprazole.