Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Persistent Chlamydiae and chronic arthritis.

Cheryl Villareal1, Judith A Whittum-Hudson, Alan P Hudson

  • 1Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA. ahudson@med.wayne.edu

Arthritis Research
|March 7, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quo vadis reactive arthritis?

Current opinion in rheumatology·2022
Same author

How best to treat "long-haulers" with reactive arthritis?

The Journal of family practice·2021
Same author

Reactive Arthritis Update: Spotlight on New and Rare Infectious Agents Implicated as Pathogens.

Current rheumatology reports·2021
Same author

Reactive arthritis, a missing link: comment on the recent article from Sepriano <i>et al</i>.

Annals of the rheumatic diseases·2020
Same author

Chlamydia-Induced Reactive Arthritis: Disappearing Entity or Lack of Research?

Current rheumatology reports·2019
Same author

<i>Chlamydia pneumoniae</i>: An Etiologic Agent for Late-Onset Dementia.

Frontiers in aging neuroscience·2018
Same journal

21st European workshop for rheumatology research.

Arthritis research·2014
Same journal

21st European Workshop for Rheumatology Research, Vienna, Austria, 1-4 March 2001. Abstracts.

Arthritis research·2005
Same journal

Effects of disease modifying agents and dietary intervention on insulin resistance and dyslipidemia in inflammatory arthritis: a pilot study.

Arthritis research·2002
Same journal

Angiogenic and angiostatic factors in systemic sclerosis: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers.

Arthritis research·2002
Same journal

VLA-4-dependent and -independent pathways in cell contact-induced proinflammatory cytokine production by synovial nurse-like cells from rheumatoid arthritis patients.

Arthritis research·2002
Same journal

Abnormalities of B cell phenotype, immunoglobulin gene expression and the emergence of autoimmunity in Sjögren's syndrome.

Arthritis research·2002
See all related articles

Persistent Chlamydia trachomatis in synovial tissue may cause chronic inflammatory arthritis. Understanding these persistent forms is key to developing new treatments for chlamydial joint disease.

Area of Science:

  • Microbiology
  • Immunology
  • Rheumatology

Background:

  • Urogenital Chlamydia trachomatis infection can lead to acute inflammatory arthritis.
  • A subset of patients develop chronic disease, with the organism persisting in synovial tissue.
  • Persistent Chlamydia exhibits different metabolic characteristics than actively growing forms.

Purpose of the Study:

  • To investigate the role of persistent Chlamydia in chronic joint disease.
  • To explore the pathogenesis of chlamydial arthritis.
  • To inform the development of novel therapeutic strategies.

Main Methods:

  • Analysis of synovial tissue from patients with chronic inflammatory arthritis.
  • Characterization of Chlamydia in persistent versus actively growing states.

Related Experiment Videos

  • Review of existing research on Chlamydia pathogenesis in joint disease.

    • Main Results:

    • Chlamydia trachomatis is found in a persistent, non-replicating form in the synovium of chronic arthritis patients.
    • Metabolic differences exist between persistent and actively growing Chlamydia.
    • Chlamydia pneumoniae may also persist in the synovium and contribute to joint pathogenesis.

    Conclusions:

    • Chlamydiae play a complex role in joint disease beyond acute infection.
    • Persistent Chlamydia in synovial tissue is a significant factor in chronic arthritis.
    • New treatment approaches should consider the persistent nature of Chlamydia in joint disease.