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Allergic contact dermatitis to latanoprost
Kelly Michele Jerstad1, Erin Warshaw
1Department of Dermatology, University of Minnesota and the Minneapolis VA, Minneapolis, MN, USA.
Summary
This study reports the first known case of allergic contact dermatitis to latanoprost, a common glaucoma medication. The patient experienced eyelid reactions, highlighting the need for careful diagnosis of adverse drug reactions.
Area of Science:
- Ophthalmology
- Allergology
- Dermatology
Background:
- Glaucoma management often involves prostaglandin analogs like latanoprost.
- Adverse ocular and periocular reactions can occur with ophthalmic medications.
Observation:
- An 85-year-old male with glaucoma developed chronic tearing, red eyes, and eczematous eyelid inflammation.
- Initial treatments for presumed ocular rosacea and seborrhea were ineffective.
- Patch testing revealed allergy to Balsam of Peru, but not common preservatives.
Findings:
- Repeat testing confirmed allergic contact dermatitis (ACD) specifically to latanoprost 0.005% ophthalmic solution.
- The reaction was positive to the full latanoprost preparation, not its vehicle alone.
Implications:
- This case represents the first documented instance of ACD caused by latanoprost.
- Clinicians should consider latanoprost as a potential allergen in patients with refractory eyelid dermatitis.
- Further investigation into latanoprost's allergenic potential is warranted.