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Updated: Oct 2, 2026

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects
Published on: December 10, 2010
[Effect of opioid peptides on the repair regeneration of the bone tissue]
1Kursk State Medical University, 305041, Kursk.
Abstract:
The study is made of the effects of selective agonists of opioid receptors (DAGO--the agonist of mu-receptors, DSLET--the agonist of delta-receptors, dynorphin A,I-13,--the agonist of kappa-receptors) on reparative osteogenesis in CBA mice. The drugs were injected intraperitoneally within 7 days after bone fracture in equimolar doses: DAGO--6.3 mcg/kg, DSLET--10 mcg/kg, dynorphin A (1-13)--20.2 mcg/kg. It was established that the use of DSLET and DAGO accelerates the development of newly-synthesized spongy bone tissue in the bone regenerate. This manifested with its early appearance (4 days after the fracture) as well as higher indices of specific volumes of bone tissue in the regenerate within the experiment (7, 10, 14 days after bone fracture) in comparison with the control animal group. Dynorphin A(1-13) had no influence on regenerate formation in our experiments.
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Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...

