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Related Experiment Videos

QTc interval in infants receiving cisapride.

Satbir Chhina1, Ricardo L Peverini, Douglas D Deming

  • 1Doctor's Hospital, Laredo, TX, USA.

Journal of Perinatology : Official Journal of the California Perinatal Association
|March 16, 2002
PubMed
Summary

Cisapride treatment in infants caused corrected QT (QTc) interval prolongation in 30% of cases, but most normalized within 14 days. Early QTc monitoring can identify infants at risk.

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Area of Science:

  • Pediatric Cardiology
  • Clinical Pharmacology

Background:

  • Cisapride is used to improve gastrointestinal motility in infants.
  • The potential for cisapride to affect cardiac repolarization, specifically the corrected QT (QTc) interval, requires careful evaluation in pediatric populations.

Purpose of the Study:

  • To investigate the impact of cisapride on the QTc interval in infants over a 14-day treatment period.
  • To identify potential predictors of QTc interval prolongation during cisapride therapy.

Main Methods:

  • A prospective cohort study involving infants treated with cisapride (0.8 mg/kg/day).
  • Electrocardiograms were recorded at baseline and on days 3, 5, 7, and 14 post-initiation of cisapride.
  • Analysis focused on changes in QTc interval and the incidence of prolongation.

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Main Results:

  • Thirty percent (15 of 50) of infants experienced QTc interval prolongation (≥450 msec).
  • In most cases (13 of 15), the QTc interval normalized by day 14.
  • Infants with a QTc interval ≥2 standard deviations above the mean baseline on day 3 were significantly more likely to develop prolonged QTc intervals (p<0.0001).

Conclusions:

  • Cisapride therapy can lead to transient QTc interval prolongation in a significant proportion of infants.
  • Early identification of QTc prolongation risk, using measurements from day 3, is possible.
  • With vigilant monitoring, cisapride may be safely used to enhance gastrointestinal motility in hospitalized infants without significant cardiac complications.