[Clinical and diagnostic aspects of drug-induced hepatitis]

Drug-induced hepatitides (DIH) may manifest with a wide range of symptoms from insignificant activation of the enzymes with asthenic syndrome to severe disease with jaundice. The most informative tests for early diagnosis of medicinal lesion of the liver are biochemical tests of blood serum with determination of activity of the enzymes AlAt, AsAT, AP, GGTP. Long-term use of the drug and late diagnosis of DIH endanger drug damage to the liver. Treatment of acute drug hepatitides consists in administration of medication stimulating metabolic ability of hepatic cells. Acute DIH is characterized by the absence of splenomegaly.