Related Experiment Video

Updated: Aug 13, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

[Hematological characteristics in blood autoanalysis in children with congenital heart defects]

E F Kozar, N N Samsonova, A S Sharykin

    Klinicheskaia Laboratornaia Diagnostika
    |March 20, 2002
    PubMed

    Insights

    Automated blood analysis reveals distinct hematological differences in infants with congenital heart disease (CHD). Blue type CHD infants show increased red blood cells and lower, larger platelets compared to pale type.

    Area of Science:

    • Hematology
    • Pediatrics
    • Medical Technology

    Context:

    • Congenital heart disease (CHD) affects infant hematological status.
    • Automated blood analysis systems offer advanced diagnostic capabilities.

    Purpose:

    • To evaluate the hematological status of infants with pale and blue type congenital heart disease using automated systems.
    • To compare the accuracy and efficiency of automated versus microscopic blood analysis in pediatric patients with CHD.

    Summary:

    • Automated analysis revealed higher erythrocyte counts and hematocrit in blue type CHD infants.
    • Leukocyte formula results correlated between automated and microscopic methods.
    • Automated methods are superior for platelet count estimation, showing decreased and enlarged platelets in blue type CHD.

    Impact:

    • Automated analyzers provide accurate and productive assessment of hemopoiesis in infants with CHD.
    • This technology aids in differentiating CHD types based on hematological profiles.
    • Findings support the use of automated analyzers for comprehensive pediatric hematological evaluation.

    More Related Videos

    Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies11:59

    Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies

    Published on: September 6, 2017

    Analysis of Congenital Heart Defects in Mouse Embryos Using Qualitative and Quantitative Histological Methods08:28

    Analysis of Congenital Heart Defects in Mouse Embryos Using Qualitative and Quantitative Histological Methods

    Published on: March 10, 2020

    Related Concept Videos

    Hematopoiesis01:21

    Hematopoiesis

    The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
    Multipotency of Hematopoietic Stem Cells01:19

    Multipotency of Hematopoietic Stem Cells

    The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
    Regulation of Hematopoietic Stem Cells01:01

    Regulation of Hematopoietic Stem Cells

    All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
    Overview of Hematopoiesis01:20

    Overview of Hematopoiesis

    Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
    Developmental Phases of Hematopoiesis
    Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
    Disorders of Erythrocytes01:27

    Disorders of Erythrocytes

    Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
    Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
    A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
    On the other...
    Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

    Cardiomyopathy III: Hypertrophic Cardiomyopathy

    Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...