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[CORRECTION OF HEMOSTASIS WITH BLOOD PRODUCTS IN THE SURGICAL TREATMENT OF CONGENITAL HEART DISEASE IN INFANTS AND

M M Rybka, N N Samsonova, L G Klimovich

    Anesteziologiia I Reanimatologiia
    |February 9, 2016
    PubMed

    Insights

    Recombinant activated factor VII (Coagil VII) and prothrombin complex concentrate (protromplex-600) effectively stop bleeding in pediatric cardiac surgery. These hemostatic agents showed no adverse effects on hemodynamics, allergies, or thrombosis.

    Area of Science:

    • Pediatric Cardiac Surgery
    • Hemostasis
    • Pharmacology

    Context:

    • Neonatal and pediatric patients undergoing cardiac surgery often experience bleeding complications.
    • Effective hemostatic agents are crucial for managing blood loss during cardiopulmonary bypass procedures.
    • Limited data exists on the safety and efficacy of specific agents like Coagil VII and protromplex-600 in this vulnerable population.

    Purpose:

    • To evaluate the safety and efficiency of recombinant activated factor VII (Coagil VII) and prothrombin complex concentrate (protromplex-600) in neonatal and pediatric cardiac surgery.
    • To assess the impact of these agents on bleeding control, hemodynamics, and the occurrence of adverse events like allergic reactions and thrombosis.

    Summary:

    • A study involving 56 children (7 days to 5.5 years) undergoing congenital heart defect repair with cardiopulmonary bypass assessed Coagil VII and protromplex-600.
    • Clinical and laboratory data indicated that both Coagil VII and protromplex-600 were effective in controlling bleeding.
    • No negative hemodynamic effects, allergic reactions, or thrombosis were observed during the perioperative period.

    Impact:

    • Provides evidence for the safe and effective use of Coagil VII and protromplex-600 in pediatric cardiac surgery.
    • Offers valuable insights for anesthesiologists, surgeons, and hematologists managing bleeding disorders in young patients.
    • Contributes to improved patient outcomes by supporting hemostasis during complex surgical procedures.

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