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Updated: Aug 12, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Rare earth metal trifluoromethanesulfonates catalyzed benzyl-etherification
Atsushi Kawada1, Kayo Yasuda, Hitoshi Abe
1Nippon Steel Chemical Co., Ltd., Research & Development Laboratories, Kitakyushu, Japan. kawadaat@nscc.co.jp
Abstract:
Rare earth metal trifluoromethanesulfonates [rare earth metal triflate, RE(OTf)3] were found to be efficient catalyst for benzyl-etherification. In the presence of a catalytic amount of RE(OTf)3, condensation of benzyl alcohols and aliphatic alcohols proceeded smoothly to afford the benzyl ethers. The condensation between benzyl alcohols and thiols also proceeded, and thio ethers were obtained in good yield. In these reactions, RE(OTf)3 could be recovered easily after the reactions were completed and could be reused without loss of activity.
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