Related Experiment Videos
Daphnicyclidins J and K, unique polycyclic alkaloids from Daphniphyllum humile
Hiroshi Morita1, Naotoshi Yoshida, Jun'ichi Kobayashi
1Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
The Journal of Organic Chemistry
|April 2, 2002
Abstract:
Two Daphniphyllum alkaloids with unprecedented polycyclic skeletons, daphnicyclidins J (1) and K (2), have been isolated from the stems of Daphniphyllum humile, and the structures and relative stereochemistry were elucidated on the basis of spectroscopic data. The absolute stereochemistry of 1 was established by chemical correlation with a known-related alkaloid, daphnicyclidin D (3), through a modified Polonovski reaction.