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Related Experiment Videos

[Hydrosyringomyelia in demyelinating diseases].

E Mabel Gatto1, R Reisin, M Nogués

  • 1Departamento de Neurología. Sanatorio Mitre. FLENI. Hospital Británico. Hospital Sirio Libanés. Hospital Español. Buenos Aires. Argentina. emilagatto@fibertel.com.ar

Neurologia (Barcelona, Spain)
|April 3, 2002
PubMed
Summary

Spinal cord cavities in Devic's syndrome (DS) and multiple sclerosis (MS) differ significantly on MRI. These MRI distinctions aid in differentiating DS from MS, guiding treatment decisions.

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Area of Science:

  • Neurology
  • Radiology
  • Neuroimmunology

Background:

  • Spinal cord cavitation is common in Devic's syndrome (DS) and rare in multiple sclerosis (MS).
  • Distinguishing DS from MS is clinically significant for therapeutic choices.
  • MRI characteristics of spinal cavities in DS and MS require detailed comparison.

Observation:

  • Compared MRI findings of spinal cavities in 6 DS patients and 3 MS patients.
  • DS patients exhibited unenhanced, extensive ( >3 vertebral bodies) cavities, stable over time.
  • MS patients showed smaller ( <2 vertebral bodies), non-communicating cavities associated with spinal lesions that reduced over time.

Findings:

  • Spinal MRI revealed distinct cavity characteristics differentiating DS from MS.
  • DS cavities were extensive and stable, while MS cavities were smaller, non-communicating, and reduced with treatment.

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  • MS patients displayed spinal hyperintense T2 lesions, absent in DS patients.

    • Implications:

    • MRI findings of spinal cord cavities can help distinguish Devic's syndrome from multiple sclerosis.
    • These distinctions are crucial for appropriate therapeutic strategies in neuroinflammatory disorders.
    • Further research into the pathogenesis of spinal cavitation in DS and MS is warranted.