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Randomized clinical trials in advanced and metastatic colorectal carcinoma
Michael I Dangelica1, Margo C Shoup, Aviram Nissan
1Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. dangelim@mskcc.org
Surgical Oncology Clinics of North America
|April 4, 2002
Abstract:
The treatment of advanced colorectal cancer has long been a dilemma for clinicians. After many years of therapy limited to 5-fluorouracil (5-FU)-based chemotherapy, a number of new discoveries have significantly advanced this field in the last decade. The advent of irinotecan has given us hope for a second line chemotherapeutic agent and a possible new combination for first line chemotherapy.