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[Bullous pemphigoid induced by spironolactone]
A B Modeste1, N Cordel, Ph Courville
1Clinique Dermatologique, Unité INSERM U159, Hôpital Charles Nicolle, 1, rue de Germont, 76031 Rouen Cedex France.
Annales De Dermatologie Et De Venereologie
|April 9, 2002
Summary
Spironolactone may induce pemphigoid, a blistering skin condition. This case report details a patient whose pemphigoid resolved after discontinuing spironolactone, suggesting a causal link.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Pemphigoid is a blistering skin disease.
- Spironolactone has been implicated as a potential drug-induced cause of pemphigoid.
Observation:
- A 76-year-old patient presented with eczematiform lesions and severe pruritus.
- Diagnosis of pemphigoid was confirmed via histological and immunological investigations.
- The patient was on multiple medications, including spironolactone.
Findings:
- Discontinuation of spironolactone alone led to spontaneous regression of cutaneous lesions within 15 days.
- No relapse of pemphigoid was observed 30 months after drug withdrawal.
Implications:
- This case supports the hypothesis that spironolactone can induce pemphigoid.
- Early recognition and withdrawal of spironolactone may prevent disease progression and complications.