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Differentiated thyroid carcinoma with functional autonomy.

Subhashini Yaturu¹, Marjorie R Fowler

¹Department of Endocrinology, Overton Brooks VA Medical Center/Louisiana State University Medical Center, Shreveport, Louisiana, 71101-4295, USA.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

|April 10, 2002

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A rare case of papillary thyroid carcinoma was found within an autonomously hyperfunctioning thyroid nodule. This finding highlights that even benign-appearing, overactive thyroid nodules can harbor malignancy.

Area of Science:

Endocrinology
Oncology
Pathology

Background:

Solitary hyperfunctioning thyroid nodules are typically considered benign.
Autonomous thyroid nodules can present as painless neck masses.

Observation:

A 39-year-old woman presented with an enlarging right thyroid nodule and subclinical hyperthyroidism.
Despite no overt hyperthyroid symptoms, neck swelling increased, prompting surgical intervention.

Findings:

Pathologic analysis revealed low-grade papillary thyroid carcinoma within the hyperfunctioning nodule.
The nodule was surrounded by compressed, inactive thyroid tissue.

Implications:

The presence of an autonomous thyroid nodule does not rule out concurrent thyroid carcinoma.

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This case underscores the importance of thorough evaluation of hyperfunctioning thyroid nodules.