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[Secreted pathogenicity factors of enterobacteria]
V M Bondarenko1, A R Mavziutov, Elitza Golkocheva
1Gamaleya Research Institute of Epidemiology and Microbiology, Moscow, Russia.
Abstract:
Data on the secreted pathogenicity factors of different enterobacterial species are reviewed. Update information on toxin classification is presented. The main cytotoxic and cytotonic enterotoxins, transient pore forming toxins (RTX), cytotoxic necrotizing factor and injection toxins have been analyzed. Problems connected with the mechanism of action and genetic control of known enterobacterial toxins are discussed.
Insights
This review details secreted pathogenicity factors from enterobacterial species, updating toxin classification and analyzing key toxins like RTX and cytotoxic necrotizing factor for better understanding of bacterial virulence.
Area of Science:
- Microbiology
- Molecular Biology
- Bacteriology
Context:
- Enterobacterial species are significant human and animal pathogens.
- Understanding their secreted pathogenicity factors is crucial for disease control.
- Existing toxin classifications require updates based on new data.
Purpose:
- To review and update the classification of secreted toxins produced by enterobacteria.
- To analyze the mechanisms and genetic control of major enterobacterial toxins.
- To provide a comprehensive overview of enterobacterial pathogenicity factors.
Summary:
- This review consolidates data on secreted pathogenicity factors across various enterobacterial species.
- It presents an updated classification of bacterial toxins, including cytotoxic, cytotonic, RTX, cytotoxic necrotizing factor, and injection toxins.
- The discussion covers the mechanisms of action and genetic regulation of these toxins.
Impact:
- Provides a foundational resource for researchers studying enterobacterial infections.
- Facilitates the development of novel therapeutic and diagnostic strategies.
- Enhances understanding of bacterial pathogenesis and evolution.