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Eicosanoid-dependent cancer cachexia and wasting.

James A Ross1, Kenneth C H Fearon

  • 1Lister Research Laboratories, University Department of Clinical and Surgical Sciences, Royal Infirmary of Edinburgh, Edinburgh, UK. j.a.ross@ed.ac.uk

Current Opinion in Clinical Nutrition and Metabolic Care
|April 16, 2002
PubMed
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Reversing catabolic processes is difficult. Eicosanoids, involved in inflammation, may play a role in cancer cachexia and wasting, according to this review.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Catabolic processes are complex and poorly understood, posing a challenge for therapeutic intervention.
  • Eicosanoids, a group of unsaturated C20 fatty acids, are crucial mediators of inflammation.
  • These molecules have been increasingly implicated in the pathophysiology of cancer cachexia.

Purpose of the Study:

  • To review the fundamental biology of eicosanoids.
  • To examine the evidence linking eicosanoids to cancer cachexia and wasting syndromes.

Main Methods:

  • Literature review of eicosanoid biology.
  • Analysis of studies investigating eicosanoids in cancer cachexia.

Main Results:

Related Experiment Videos

  • Eicosanoids comprise two main classes: lipoxygenase products (leukotrienes, lipoxins) and prostanoids (prostaglandins, prostacyclin, thromboxane).
  • Evidence suggests a significant role for eicosanoids in mediating the inflammatory aspects of cancer cachexia.

    • Conclusions:

    • Understanding eicosanoid pathways is critical for addressing cancer cachexia.
    • Further research into eicosanoid modulation may offer therapeutic strategies for wasting conditions.