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Chemical synthesis and calcium release activity of N(1)-ether strand substituted cADPR mimic
Li-Jun Huang1, Yong-Yuan Zhao, Lan Yuan
1National Research Laboratory of Natural and Biomimetic Drugs, Peking University, 100083, Beijing, PR China.
Bioorganic & Medicinal Chemistry Letters
|April 18, 2002
Abstract:
8-Chloro cyclic inosine 5'-diphosphate ethoxymethyl ether 3 was synthesized by means of chemical method from protected inosine via phenylthio-type biphosphate substrate. The detection of Ca(2+) release activity shows that 3 is a potent agonist of cADPR and has activity in intact Hela cells.