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Hydrophobic modifications at 1-phosphate of inositol 1,4,5-trisphosphate analogues enhance receptor binding
Waka Nakanishi1, Kazuya Kikuchi, Takanari Inoue
1Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
Bioorganic & Medicinal Chemistry Letters
|April 18, 2002
Abstract:
Inositol 1,4,5-trisphosphate (IP(3)) analogues were synthesized in order to investigate the importance of the environment of 1-phosphate of IP(3) for strong binding to the IP(3) receptor. Our results show that hydrophobic modifications of the 1-phosphate moiety enhance the binding affinity, with considerable latitude of substituent structure.