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[Prolactinomas: neurosurgical aspects].

Oswaldo Inácio Tella1, Marco Antonio Herculano, Rosana Delcello

  • 1Disciplina de Neurocirurgia, Universidade Federal de São Paulo, Brasil. detella.ncir@epm.br

Arquivos De Neuro-Psiquiatria
|April 20, 2002
PubMed
Summary

This study on prolactin secreting pituitary adenomas found that pure prolactinomas are often microadenomas, while mixed adenomas can cause visual issues. Treatment is typically medical, with surgery reserved for medication intolerance or visual deficits.

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Area of Science:

  • Endocrinology
  • Neurosurgery
  • Oncology

Context:

  • Pituitary adenomas are common tumors, with prolactinomas being the most frequent type.
  • Understanding the clinical presentation and treatment outcomes of different prolactinoma subtypes is crucial for patient management.

Purpose:

  • To analyze the clinical characteristics, treatment strategies, and surgical outcomes of 38 cases of prolactin secreting pituitary adenomas.
  • To differentiate between pure prolactinomas and mixed pituitary adenomas based on hormonal profile and clinical presentation.

Summary:

  • Prolactinomas were classified into three groups: pure prolactinomas (often microadenomas), GH-PRL and other combinations, and plurihormonal adenomas.
  • Pure prolactinomas typically present without visual symptoms, whereas mixed adenomas frequently cause visual disturbances.

Related Experiment Videos

  • Medical management is the primary treatment for prolactinomas; surgery is indicated for medication intolerance or visual impairment.

    • Impact:

    • This study highlights the distinct clinical behaviors of different prolactinoma subtypes, aiding in tailored treatment approaches.
    • The findings emphasize the importance of considering visual symptoms in the diagnosis and management of mixed pituitary adenomas.
    • Achieving total tumor resection in 50% of surgical cases provides valuable data on surgical success rates for these complex tumors.