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Nickel(0)/dihydroimidazol-2-ylidene complex catalyzed coupling of aryl chlorides and amines
Christophe Desmarets1, Raphaël Schneider, Yves Fort
1Synthèse Organique et Réactivité, UMR 7565, Université Henri Poincaré, Nancy I, Faculté des Sciences, BP 239, 54506 Vandoeuvre les Nancy Cedex, France.
The Journal of Organic Chemistry
|April 27, 2002
Abstract:
A general and simple nickel-catalyzed coupling of aryl chlorides and amines is reported. The scope and limitations of the coupling process using Ni(0), 1,3-bis(2,6-diisopropylphenyl)dihydroimidazol-2-ylidene, and NaO-t-Bu as base were investigated. Secondary cyclic and acyclic amines and anilines provided the arylamine coupling products in good to excellent yields. Compared to palladium-catalyzed aminations, this procedure offers an alternative route to N-substituted anilines starting from readily available aryl chlorides.