Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lymph nodes during antiretroviral therapy.

H J Stellbrink1, J van Lunzen

  • 1Infectious Diseases Outpatient Clinic, University Hospital Eppendorf, Hamburg, Germany. stellbri@uke.uni-hamburg.de

Current Opinion in Infectious Diseases
|April 30, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High prevalence of comorbidities and use of concomitant medication in treated people living with HIV in Germany - results of the BESIDE study.

International journal of STD & AIDS·2020
Same author

High prevalence of recreational and illicit drug use in German people living with HIV with a potential for drug-drug interactions with antiretroviral therapy.

International journal of STD & AIDS·2020
Same author

Virological failure after 1 year of first-line ART is not associated with HIV minority drug resistance in rural Cameroon .

The Journal of antimicrobial chemotherapy·2014
Same author

Hodgkin lymphoma is as common as non-Hodgkin lymphoma in HIV-positive patients with sustained viral suppression and limited immune deficiency: a prospective cohort study.

HIV medicine·2014
Same author

[Cost of Illness of HIV Patients under Anteretroviral Therapy in Germany - Results of the 48-Week Interim Analysis of the Prospective Multicentre Observational Study 'CORSAR'].

Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany))·2014
Same author

Immune activation despite suppressive highly active antiretroviral therapy is associated with higher risk of viral blips in HIV-1-infected individuals.

HIV medicine·2014
Same journal

Use of gloves: current evidence vs. current use.

Current opinion in infectious diseases·2026
Same journal

Understanding challenges to prevention of healthcare related infections.

Current opinion in infectious diseases·2026
Same journal

Harnessing next-generation microbial diagnostics to optimize infection management in immunocompromised hosts.

Current opinion in infectious diseases·2026
Same journal

Epidemiology, treatment and outcomes of antimicrobial-resistant infections in hematopoietic stem cell transplant recipients.

Current opinion in infectious diseases·2026
Same journal

Dengue and chikungunya vaccines past, present and future: implications for travelers.

Current opinion in infectious diseases·2026
Same journal

Oropouche virus: viral evolution, epidemiological trends, and challenges for control.

Current opinion in infectious diseases·2026
See all related articles

Highly active antiretroviral therapy suppresses HIV replication in lymphoid tissue, but latent virus may cause rebound. Further lymphoid tissue analysis is needed to understand complete viral suppression and immune recovery potential.

Area of Science:

  • Immunology
  • Virology
  • Infectious Diseases

Background:

  • Highly active antiretroviral therapy (HAART) effectively reduces human immunodeficiency virus (HIV) replication.
  • Viral RNA can persist in lymphoid tissues even with undetectable plasma viremia during HAART.
  • Latent HIV infection in resting cells is a key factor for viral rebound after treatment cessation.

Purpose of the Study:

  • To investigate the potential for complete viral suppression during HAART.
  • To assess the possibility of full immune reconstitution in HIV patients on therapy.
  • To determine the role of lymphoid tissue analysis in understanding HIV persistence and recovery.

Main Methods:

  • Analysis of viral RNA production in lymphoid tissue.
  • Monitoring of plasma viremia during HAART.

Related Experiment Videos

  • Assessment of immune activation markers.
  • Evaluation of CD4+ T cell counts in lymphoid tissue.

    • Main Results:

    • HAART rapidly decreases viral replication in lymphoid tissue.
    • Persistent viral RNA in lymphoid tissue is observed despite suppressed plasma viremia.
    • Immune activation declines and CD4+ T cell counts rise in lymphoid tissue during therapy.
    • The potential for complete viral eradication and immune reconstitution remains unclear.

    Conclusions:

    • Lymphoid tissue harbors persistent HIV replication and latent reservoirs.
    • Understanding lymphoid tissue dynamics is crucial for achieving complete viral suppression.
    • Further research is needed to explore complete immune reconstitution and HIV eradication strategies.