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Related Experiment Videos

[Acute autoimmune polyradiculoneuropathies].

O Papazian1, I Alfonso

  • 1División de Neurofisiología Clínica, Miami Children's Hospital, Universidad de Miami, Florida 33155, USA. oscar.papazian@mch.com

Revista De Neurologia
|May 4, 2002
PubMed
Summary
This summary is machine-generated.

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Landry Guillain Barré Strohl Syndrome (LGBS) is an autoimmune polyradiculoneuropathy impacting adults. Diagnosis involves progressive weakness and absent reflexes, with subtypes including demyelinating and axonal forms.

Area of Science:

  • Neurology
  • Immunology
  • Autoimmune Diseases

Context:

  • Landry Guillain Barré Strohl Syndrome (LGBS) is an acute, autoimmune polyradiculoneuropathy.
  • It affects adults aged 19-59 years with an incidence of 1.7/100,000/year.
  • LGBS is characterized by progressive motor weakness and absent muscle stretch reflexes.

Purpose:

  • To outline the diagnostic criteria for LGBS.
  • To describe the supporting features, subtypes, and treatment modalities for LGBS.
  • To provide a comprehensive overview of this neurological disorder.

Summary:

  • Diagnostic criteria include progressive motor weakness in multiple limbs and absent reflexes.
  • Supporting features include symmetrical limb involvement, cranial nerve deficits, autonomic dysfunction, and specific CSF and nerve conduction findings.

Related Experiment Videos

  • LGBS has four subtypes: acute inflammatory demyelinating polyradiculoneuropathy (90%), Miller Fisher syndrome (5%), acute motor axonal neuropathy, and acute motor sensory axonal neuropathy (5% combined).

    • Impact:

    • Early and accurate diagnosis of LGBS is crucial for timely management.
    • Understanding the subtypes aids in predicting disease course and treatment response.
    • Effective treatment includes supportive care and immunotherapy, such as intravenous IgG and plasmapheresis.