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Gene for integrin-associated protein (IAP, CD47): physical mapping, genomic structure, and expression studies in
Jörg Schickel1, Katharina Stahn, Klaus-Peter Zimmer
1Institut für Klinische Chemie und Laboratoriumsdiagnostik, Klinikum der Friedrich-Schiller Universität Jena, Germany. joerg.schickel@med.uni-jena.de
Abstract:
Integrin-associated protein (IAP) is a widely expressed membrane protein with multiple functions in immunological and neuronal processes. Having physically mapped the IAP gene into a BAC/PAC contig covering approximately 1 Mb on human chromosome 3ql3.1-q13.2, we determined the genomic organization of the gene, established its expression in skeletal muscle, and identified a novel splice variant. Our expression studies demonstrate expression of integrin-associated protein in the t-tubular system and the euchromatin of skeletal muscle cells where its function thus far is not known.