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[Leiomyosarcoma and transitional cell carcinoma in the urinary bladder: a case report]
Motohide Uemura1, Kensaku Nishimura, Toshiaki Hirai
1Department of Urology, Osaka Rosai Hospital.
Hinyokika Kiyo. Acta Urologica Japonica
|May 8, 2002
Summary
A 74-year-old man presented with asymptomatic hematuria and was diagnosed with both leiomyosarcoma and transitional cell carcinoma of the bladder. Despite radical cystectomy, he succumbed to metastatic disease and local recurrence within six months.
Area of Science:
- Urology
- Oncology
- Pathology
Background:
- Transitional cell carcinoma (TCC) is the most common bladder cancer.
- Leiomyosarcoma is a rare mesenchymal tumor of the bladder.
- Concurrent TCC and leiomyosarcoma of the bladder is exceptionally rare.
Observation:
- A 74-year-old male presented with asymptomatic macroscopic hematuria.
- Previous history of transurethral resection of bladder tumor (TURBT) for TCC 30 years prior.
- Pelvic CT revealed two invasive bladder tumors: a 5 cm tumor on the dome and a 1 cm tumor on the lateral wall.
Findings:
- Pathological examination of resected tumors confirmed both leiomyosarcoma and TCC.
- The patient underwent radical cystectomy with bilateral cutaneousureterostomy.
- Tumor histology revealed a rare co-occurrence of two distinct bladder malignancies.
Implications:
- This case highlights the diagnostic challenge of concurrent rare bladder tumors.
- Aggressive management with radical cystectomy may be indicated for multifocal, invasive bladder tumors.
- The prognosis remains poor, with a high risk of recurrence and metastasis even after extensive treatment.