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Angiogenesis therapy in ischemic disease.

J S Silvestre¹, B I Lévy

¹INSERM U541, hôpital Lariboisière, institut fédératif de recherche circulation-Paris 7, université Paris 7-Denis Diderot, 75475 Paris.

Archives Des Maladies Du Coeur Et Des Vaisseaux

|May 10, 2002

Summary

Therapeutic angiogenesis, the development of new blood vessels, offers hope for treating vascular occlusive diseases and ischemia. Research explores growth factors, cell therapies, and oral drugs to promote vessel formation, aiming to improve tissue health.

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Area of Science:

Cardiovascular Biology
Regenerative Medicine
Vascular Biology

Background:

Vascular occlusive diseases lead to tissue ischemia, with collateral vessel development influencing disease severity.
Neovascularization in ischemic tissues can preserve function and is considered a therapeutic target.
Advances in gene technology and animal models facilitate research into therapeutic angiogenesis.

Purpose of the Study:

To review current therapeutic angiogenesis strategies for ischemic diseases.
To evaluate the potential of various approaches, including growth factors, cell-based therapies, and oral medications.
To highlight the need for awareness of potential side effects of angiogenic agents.

Main Methods:

Review of recent studies on therapeutic angiogenesis.

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Analysis of strategies using recombinant angiogenic growth factors (VEGF, FGF).

Exploration of cell-based therapies and oral pro-angiogenic drugs.

Main Results:

Recombinant growth factors (VEGF, FGF) show feasibility for enhancing angiogenesis in limb and myocardial ischemia.
Cell-based therapies, including endothelial progenitor cells, are being developed.
Oral pro-angiogenic drugs represent a potential alternative strategy.

Conclusions:

Therapeutic angiogenesis strategies show promise for treating ischemic diseases.
Various approaches, including growth factors and cell therapies, are under investigation.
Careful consideration of biological effects and potential side effects is crucial for clinical application.