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[Inhalation anesthesia with halogen-containing anesthetics in children]
Insights
This study compared three inhalation anesthetics in 158 children undergoing surgery. Ethrane and isoflurane showed a less pronounced hemodynamic response compared to fluothane, indicating their suitability for pediatric anesthesia.
Area of Science:
- Pediatric Anesthesiology
- Pharmacology of Inhalational Anesthetics
Context:
- Surgical procedures in children require careful anesthetic management.
- Assessing the impact of different anesthetic induction methods on pediatric patients is crucial.
Purpose:
- To compare the effects of ethrane, fluothane, and isoflurane inhalation anesthesia on central hemodynamics, cardiointervalograms, and respiratory function in children.
- To evaluate the safety and efficacy of different anesthetic induction techniques in pediatric surgical patients.
Summary:
- The study involved 158 children (3-16 years) divided into three groups receiving different anesthetic inhalations (ethrane, fluothane, isoflurane) with nitrous oxide and oxygen.
- Ethrane and isoflurane induction times were longer (4-12 min) than fluothane (3-5 min).
- Ethrane and isoflurane anesthesia resulted in less pronounced central hemodynamic reactions compared to fluothane, which decreased sympathetic tone and increased parasympathetic activity.
Impact:
- Findings suggest that ethrane and isoflurane may offer a more stable hemodynamic profile during induction in pediatric anesthesia compared to fluothane.
- The study supports the use of inhalation anesthetics in pediatric surgery, highlighting the need for careful agent selection based on patient response.
Abstract:
The study was carried out in 158 children aged 3-16 years operated on in an inpatient setting. The patients were divided into 3 groups with different types of induction narcosis: 1) ethrane inhalation up to 3 vol% and N2O with O2 in 1:1 ratio (56 pts); 2) fluothane up to 3.5 vol% and N2O with O2 in 2:1 ratio (87 pts), and 3) isoflurane inhalation up to 3 vol% and N2O with O2 in 1:1 ratio (15 children). Central hemodynamics, cardiointervalograms, and external respiration function were studied. Ethrane and isoflurane induction was longer (4-12 min) than fluothane induction (3-5 min). Anesthesia with ethrane and isoflurane in combination with N2O with O2 led to a less pronounced reaction of the central hemodynamics than fluothane anesthesia, which led to a decrease of the sympathic tone and increase in the activity of the parasympathetic component of the autonomic nervous system. Analyzing a vast scope of clinical material on the use of inhalation anesthetics and all the pros and contras, the authors conclude that inhalation anesthetics can be used in children.