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Updated: Jul 26, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
New terpenoids from Haplopappus multifolius
G T Maatooq1, A A Gohar, J J Hoffmann
1Department of Pharmacognosy, Faculty of Pharmacy, University of Mansoura, Egypt. galaltm@mans.edu.eg
Abstract:
The chemical investigation of the aerial parts of Haplopappus multifolius afforded the new monoterpene 2,9-epoxy-p-menth-6-en-8-ol (7, haplopappol), the new monoterpenoid ester 9-cis-p-coumaroyloxy-alpha-terpineol (8, haplofolin), the new diterpene 18-hydroxylabda-7,13Z-dien-15-oic acid (6) and its known E-isomer (5). In addition, the known dihydroflavones 3',5-dihydroxy-4',7-dimethoxydihydroflavone and 3',4',5-trihydroxy-7-methoxydihydroflavone and the known dihydroflavonols 3',5-dihydroxy-4',7-dimethoxydihydroflavonol and 3',4',5-trihydroxy-3-acetyl-7-methoxydihydroflavonol were also obtained. The structural assignments of these compounds were made possible by the different spectroscopic measurements.
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