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Related Experiment Videos

Intolerance to aspirin.

C L Casterline

    American Family Physician
    |November 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Aspirin intolerance syndrome, affecting 2.4% of asthma patients, involves rhinitis, sinusitis, and asthma. Management requires avoiding aspirin and treating symptoms.

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    Area of Science:

    • Clinical immunology
    • Pulmonology
    • Otolaryngology

    Background:

    • Aspirin intolerance syndrome presents with rhinitis, sinusitis, nasal polyposis, and asthma.
    • This syndrome can occur with or without prior adverse reactions to aspirin.
    • The prevalence in asthma and/or rhinitis patients is estimated at 2.4%.

    Purpose of the Study:

    • To define the characteristics and prevalence of aspirin intolerance syndrome.
    • To identify cross-reactive substances and potential mechanisms.
    • To outline current treatment strategies for aspirin intolerance.

    Main Methods:

    • Review of clinical characteristics of aspirin intolerance syndrome.
    • Analysis of patient data regarding reactions to aspirin and related compounds.

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  • Evaluation of treatment outcomes based on avoidance and symptomatic therapy.

    • Main Results:

    • Aspirin intolerance syndrome includes respiratory symptoms and asthma.
    • Cross-reactivity observed with indomethacin, morphine, codeine, and dyes, but not sodium salicylate or acetaminophen.
    • The underlying mechanism is non-immunologic.

    Conclusions:

    • Aspirin intolerance syndrome is a distinct clinical entity.
    • Strict avoidance of aspirin and managing associated respiratory and asthma symptoms are key treatment components.
    • Further research is needed to elucidate the non-immunologic mechanism.