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Updated: Oct 1, 2026

Kinetic Visualization of Single-Cell Interspecies Bacterial Interactions
Published on: August 5, 2020
Kinetic resolutions of indan derivatives using bacteria
Naoki Tarui1, Hayao Watanabe, Kohji Fukatsu
1Pharmaceutical Research Division, Takeda Chemical Industries, Ltd., Osaka, Japan. Tarui_Naoki@takeda.co.jp
Abstract:
Racemic indan derivatives have been resolved by the hydrolysis of amide bonds using Corynebacterium ammoniagenes IFO12612 to produce (S)-amine and (R)-amides. In the kinetic resolution of 1 (N-12-(6-methoxy-indan-1-yl)ethyl]acetamide), it was possible to run the reaction to 44% conversion on a 10-g scale, obtaining (S)-amine 4 ((S)-2-(6-methoxy-indan-1-yl)ethylamine) at >99% enantiomeric excess (ee) and (R)-1 at 98% ee.
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