Self-curing acrylic formulations containing PMMA/PCL composites: properties and antibiotic release behavior

Area of Science:

• Materials Science
• Biomaterials Engineering
• Polymer Chemistry

Background:

• Acrylic composites are widely used in biomedical applications.
• Developing biodegradable materials with controlled drug release is crucial for medical implants.
• Poly(methyl methacrylate)-poly(epsilon-caprolactone) (PMMA/PCL) systems offer tunable properties for composite development.

Purpose of the Study:

• To prepare and characterize partially biodegradable acrylic composites using PMMA/PCL beads.
• To evaluate the in vitro degradation and mechanical properties of these composites.
• To assess the potential of these composites as carriers for local antibiotic release.

Main Methods:

• PMMA/PCL beads were synthesized in various weight ratios.
• Composites were formed by mixing PMMA/PCL beads with methyl methacrylate (MMA).
• In vitro degradation was studied in simulated body fluid; mechanical properties were tested (compressive and tensile).
• Vancomycin release kinetics were evaluated from drug-loaded composites.

Main Results:

• Composites exhibited microheterogeneity influencing curing parameters.
• Weight loss of approximately 2% was observed after 8 weeks for PCL-rich composites.
• PMMA/PCL addition decreased compressive strength and elastic modulus compared to pure PMMA.
• Drug-elution studies showed the PMMA/PCL 86:14 composite released 90% of vancomycin in 2 months.

Conclusions:

• PMMA/PCL composites demonstrate partial biodegradability and altered mechanical properties.
• The PMMA/PCL 86:14 composite is an effective vancomycin carrier for sustained local antibiotic release.
• These composites show potential for use in non-load bearing graft applications requiring antibiotic delivery.