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Spliceosomal snRNAs: Mg(2+)-dependent chemistry at the catalytic core?
Tommaso Villa1, Jeffrey A Pleiss, Christine Guthrie
1Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94143, USA.
Abstract:
Since the discovery of self-splicing RNAs, it has been suspected that the snRNAs are the catalytic components of the spliceosome. Recent evidence supports both the catalytic potential of the spliceosomal snRNAs and their resemblance to elements of group II introns.
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