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Heart weight and heart weight/body weight coefficient in malnourished adults
Daniel Ferreira da Cunha1, Selma Freire de Carvalho da Cunha, Marlene Antônia dos Reis
1Faculdade de Medicina do Triângulo Mineiro, Uberaba. dfcuntro@mednet.com.br
Insights
Chronic malnutrition in adults is associated with lighter hearts and a higher heart weight to body weight ratio. This suggests potential myocardial preservation despite significant weight loss.
Area of Science:
- Cardiovascular Physiology
- Nutritional Science
- Pathology
Background:
- Chronic malnutrition significantly impacts various physiological systems.
- Understanding cardiac adaptations in malnutrition is crucial for clinical management.
Purpose of the Study:
- To compare heart weight and heart weight/body weight coefficient in adults with and without chronic malnutrition.
- To investigate potential cardiac remodeling in response to malnutrition.
Main Methods:
- Autopsy data from 210 adults were analyzed.
- Exclusion criteria included specific diseases and conditions.
- Malnutrition defined as Body Mass Index (BMI) <18.5kg/m2; heart weight/body weight coefficient (HW/BW x 100) calculated.
Main Results:
- Malnourished group (n=15) had lower BMI (15.9±1.7 vs 21.3±2.5kg/m2) and heart weight (267.3±59.8 vs 329.1±50.4g) compared to controls (n=21).
- Malnourished individuals exhibited a higher HW/BW coefficient (0.64±0.12% vs 0.57±0.09%).
- Significant positive correlations found between heart weight and BMI (r=0.52), and heart weight and body weight (r=0.65).
Conclusions:
- Adults with chronic malnutrition present with lighter hearts and an elevated HW/BW coefficient.
- Findings suggest possible myocardial preservation mechanisms in malnutrition.
- Increased relative cardiac connective tissue and vasculature may contribute to observed changes.
Objective:
To compare the heart weight and the heart weight/body weight coefficient of adults with and without chronic malnutrition.
Methods:
In an initial case series of 210 autopsies performed in adults, we recorded body and heart weights and calculated the heart weight/body weight coefficients (HW/BW x 100). The exclusion criteria were as follows: positive serology for Chagas' disease, edema, obesity, heart diseases, hepatopathies, nephropathies, and systemic arterial hypertension. Malnutrition was characterized as a body mass index <18.5kg/m2. Differences with p<0.05 were considered significant.
Results:
Individuals in the malnourished (n=15) and control (n=21) groups were statistically different, respectively, in regard to body mass index (15.9+/-1.7 versus 21.3+/-2.5kg/m2), heart weight (267.3+/-59.8 versus 329.1+/-50.4g), and the HW/BW coefficient (0.64+/-0.12 versus 0.57+/-0.09%). A positive and significant correlation was observed between heart weight and body mass index (r=0.52), and between heart weight and body weight (r=0.65).
Conclusion:
Malnourished individuals have lighter hearts and a greater HW/BW coefficient than non-malnourished individuals do. These findings indicate a possible preservation of the myocardium in relation to the intensity of weight loss associated with the probable relative increase in cardiac connective tissue and heart blood vessels.
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