Heart weight and heart weight/body weight coefficient in malnourished adults

Daniel Ferreira da Cunha1, Selma Freire de Carvalho da Cunha, Marlene Antônia dos Reis

  • 1Faculdade de Medicina do Triângulo Mineiro, Uberaba. dfcuntro@mednet.com.br

Insights

Chronic malnutrition in adults is associated with lighter hearts and a higher heart weight to body weight ratio. This suggests potential myocardial preservation despite significant weight loss.

Area of Science:

  • Cardiovascular Physiology
  • Nutritional Science
  • Pathology

Background:

  • Chronic malnutrition significantly impacts various physiological systems.
  • Understanding cardiac adaptations in malnutrition is crucial for clinical management.

Purpose of the Study:

  • To compare heart weight and heart weight/body weight coefficient in adults with and without chronic malnutrition.
  • To investigate potential cardiac remodeling in response to malnutrition.

Main Methods:

  • Autopsy data from 210 adults were analyzed.
  • Exclusion criteria included specific diseases and conditions.
  • Malnutrition defined as Body Mass Index (BMI) <18.5kg/m2; heart weight/body weight coefficient (HW/BW x 100) calculated.

Main Results:

  • Malnourished group (n=15) had lower BMI (15.9±1.7 vs 21.3±2.5kg/m2) and heart weight (267.3±59.8 vs 329.1±50.4g) compared to controls (n=21).
  • Malnourished individuals exhibited a higher HW/BW coefficient (0.64±0.12% vs 0.57±0.09%).
  • Significant positive correlations found between heart weight and BMI (r=0.52), and heart weight and body weight (r=0.65).

Conclusions:

  • Adults with chronic malnutrition present with lighter hearts and an elevated HW/BW coefficient.
  • Findings suggest possible myocardial preservation mechanisms in malnutrition.
  • Increased relative cardiac connective tissue and vasculature may contribute to observed changes.
Abstract

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