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Drugs Used in Lower Respiratory Disorders: Overview

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Related Experiment Video

Updated: Jul 24, 2026

A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii

A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii

Published on: January 2, 2017

Azithromycin for acute bronchitis: a randomised, double-blind, controlled trial.

Arthur T Evans¹, Shahid Husain, Lakshmi Durairaj

¹Collaborative Research Unit, Department of Medicine, Cook County Hospital and Rush Medical College, Chicago, IL 60612, USA. aevans@cchil.org

Lancet (London, England)

|May 22, 2002

Summary

Azithromycin offers no benefit over vitamin C for acute bronchitis treatment. Further research is needed to determine the optimal management for this common respiratory condition.

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Area of Science:

Respiratory Medicine
Clinical Trials
Pharmacology

Background:

Acute bronchitis is frequently treated with azithromycin, despite a lack of evidence supporting its efficacy.
The effectiveness of azithromycin for acute bronchitis remains largely uninvestigated in rigorous clinical trials.

Purpose of the Study:

To evaluate the efficacy of azithromycin compared to vitamin C in treating acute bronchitis.
To assess the impact on health-related quality of life in patients with acute bronchitis.

Main Methods:

A randomized, double-blind, controlled trial was conducted with adults diagnosed with acute bronchitis.
Participants received either azithromycin or vitamin C for 5 days, alongside dextromethorphan and albuterol.
The primary outcome measured was improvement in health-related quality of life at 7 days, analyzed by intention to treat.

Main Results:

Azithromycin showed no significant improvement in health-related quality of life compared to vitamin C at 7 days (difference 0.03, p=0.8).
Return to usual activities by day 7 was similar between groups (89% for both), with no statistically significant difference.
Adverse effect frequencies were comparable, with slightly more discontinuations due to perceived side effects in the vitamin C group.

Conclusions:

Azithromycin is not superior to low-dose vitamin C for treating acute bronchitis.
Additional research is necessary to establish the most effective treatment strategies for acute bronchitis.