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SHPS-1, a multifunctional transmembrane glycoprotein.

Kumi Oshima1, A R M Ruhul Amin, Atsushi Suzuki

  • 1Department of Molecular Pathogenesis, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.

FEBS Letters
|May 23, 2002
PubMed
Summary

Signal regulatory protein family member SHPS-1 interacts with CD47 and acts as a scaffold protein. SHPS-1 influences numerous biological processes, including cell growth, immune cell regulation, and neuronal development.

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Area of Science:

  • Cell biology
  • Immunology
  • Neuroscience

Background:

  • SHPS-1 is a member of the SIRP family, interacting with CD47 via its amino-terminal immunoglobulin-like domain.
  • The intracellular region of SHPS-1 functions as a scaffold protein, binding to adapter proteins.
  • SHPS-1 is implicated in diverse biological functions, including cell growth suppression and immune cell regulation.

Purpose of the Study:

  • To review the multifaceted roles of SHPS-1 in various biological phenomena.
  • To discuss the molecular mechanisms underlying SHPS-1's functions.
  • To explore the significance of SHPS-1 in biology.

Main Methods:

  • Literature review of recent studies on SHPS-1.
  • Analysis of molecular interactions involving SHPS-1 and CD47.

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  • Discussion of SHPS-1's involvement in cellular processes.

    • Main Results:

    • SHPS-1 mediates cell-cell interactions through CD47 binding.
    • SHPS-1 regulates immune cells, red blood cell recognition, and macrophage function.
    • SHPS-1 is crucial for skeletal muscle differentiation, circadian clock entrainment, and neuronal survival/synaptogenesis.

    Conclusions:

    • SHPS-1 is a versatile protein with diverse roles in cellular processes.
    • Understanding SHPS-1's mechanisms provides insights into cell-cell interactions and development.
    • Further research is needed to fully elucidate the biological significance of SHPS-1.