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Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
Efficient synthesis of IPL576,092: a novel anti-asthma agent
Yaping Shen1, David L Burgoyne
1Inflazyme Pharmaceuticals Ltd., Suite 425, 5600 Parkwood Way, Richmond, British Columbia, Canada V6V 2M2. yshen@inflazyme.com
The Journal of Organic Chemistry
|May 25, 2002
Abstract:
An enantioseletive synthesis of the novel anti-asthma agent IRL576,092 (2) is described. The synthetic route developed involves stereoselective 1,2-reduction of the enone carbonyl functionality of 6 and subsequent hydroboration as the key steps. Starting from the commercially available 5-androsten-3beta-ol-17-one 3, this approach affords IPL576,092 (2) in nine steps with overall yields of 25%, employing a limited number of chromatographic steps.
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