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Ascorbic acid supplement during luteal phase in IVF
Georg Griesinger1, Katharina Franke, Cordelia Kinast
1Department of Obstetrics and Gynecology, University of Vienna, Waehringer Guertel, Austria.
Purpose:
To evaluate the impact of ascorbic acid of different doses as additional support during luteal phase in infertility treatment by means of a prospective, randomized, placebo-controlled, group comparative, double-blind study.
Methods:
Voluntary daily oral intake of either ascorbic acid (1, 5, or 10 g/day) or Placebo for 14 days after follicle aspiration for IVF-ET procedure. Data was obtained on 620 cases of women, age <40 years, undergoing first IVF-embryo transfer cycles in two private outpatient infertility clinics. All women were stimulated by the same protocol. The mean age was 31.73 (+/- 4.4 SD) years.
Results:
No differences in clinical pregnancy rate and implantation rate were noted in statistical logistic regression analysis between the four intake groups.
Conclusions:
There was no clinical evidence of any beneficial effect, as defined by main outcome measures, of ascorbic acid on IVF-ET. Our data suggest there is no obvious value of high dosed intake of vitamin C during luteal phase in infertility treatment.