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Ascorbic acid supplement during luteal phase in IVF.

Georg Griesinger1, Katharina Franke, Cordelia Kinast

  • 1Department of Obstetrics and Gynecology, University of Vienna, Waehringer Guertel, Austria.

Journal of Assisted Reproduction and Genetics
|May 31, 2002
PubMed
Summary
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High-dose ascorbic acid (vitamin C) supplementation did not improve pregnancy or implantation rates in women undergoing in vitro fertilization (IVF). This study found no benefit for vitamin C during the luteal phase of IVF treatment.

Area of Science:

  • Reproductive Endocrinology
  • Nutritional Science
  • In Vitro Fertilization (IVF)

Background:

  • The luteal phase is critical for successful implantation in assisted reproductive technologies.
  • Ascorbic acid (vitamin C) is an antioxidant with potential roles in reproductive health.
  • Optimizing luteal phase support is crucial for improving IVF-ET outcomes.

Purpose of the Study:

  • To investigate the efficacy of varying doses of ascorbic acid as an adjunct therapy during the luteal phase of IVF-ET.
  • To determine if ascorbic acid supplementation impacts clinical pregnancy and implantation rates.

Main Methods:

  • A prospective, randomized, double-blind, placebo-controlled study involving 620 women undergoing their first IVF-ET cycles.
  • Participants received daily oral doses of ascorbic acid (1g, 5g, or 10g) or a placebo for 14 days post-follicle aspiration.

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  • Standardized stimulation protocols were used across two infertility clinics.

    • Main Results:

    • Statistical analysis revealed no significant differences in clinical pregnancy rates among the four groups (ascorbic acid doses vs. placebo).
    • Implantation rates did not differ significantly between women receiving ascorbic acid and those receiving placebo.
    • Logistic regression analysis confirmed the lack of a beneficial effect of ascorbic acid on key IVF-ET outcomes.

    Conclusions:

    • Ascorbic acid supplementation during the luteal phase of IVF-ET demonstrated no clinical benefit regarding pregnancy or implantation.
    • High-dose vitamin C intake does not appear to enhance outcomes in infertility treatment.
    • Further research may be needed to explore other potential roles or optimal timing of vitamin C in reproductive medicine.