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[Aminoglycoside antibiotics and post-antibiotic effects]
Sandra Stefan-Mikić1, Ana Sabo, Milotka Fabri
1Klinika za infektivne bolesti, Klinicki centar, Novi Sad, Medicinski fakultet, Novi Sad. stefanns@eunet.yu
Medicinski Pregled
|June 1, 2002
Summary
Despite education on aminoglycoside antibiotics and their postantibiotic effect, doctors continue old prescribing habits. Single daily dosing, which is equally or more effective and less toxic, is not widely adopted.
Area of Science:
- Pharmacology and Infectious Diseases
- Antimicrobial Stewardship
Context:
- Physicians' prescribing habits for aminoglycoside antibiotics remain largely unchanged despite awareness of the postantibiotic effect.
- A health education course aimed to modify prescription practices regarding aminoglycoside antibiotics and their postantibiotic effect.
Purpose:
- To evaluate the effectiveness of a health education course in changing physicians' prescribing habits for aminoglycoside antibiotics.
- To promote the adoption of single daily dosing regimens based on the understanding of aminoglycoside postantibiotic effect and toxicity profiles.
Summary:
- The study assessed the adoption of single daily aminoglycoside dosing post-education, finding varied implementation rates across different clinical settings.
- The Clinic for Infectious Diseases (63.6%) and Outpatient Health Care Center (41.2%) showed some adoption, while General Practice, Pediatrics, and ENT clinics did not use this regimen.
Impact:
- The educational intervention failed to significantly alter established prescribing behaviors for aminoglycoside antibiotics.
- Physicians' adherence to traditional multiple daily dosing regimens persists, indicating a need for further strategies to improve antimicrobial stewardship.