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Blood pressure measurement in research
Gianfranco Parati1, Peter de Leeuw, Miklos Illyes
1Department of Cardiology, University of Milano-Bicocca and Istituto Auxologico Italiano, Milan, Italy. gianfranco.parati@unimib.it
Blood Pressure Monitoring
|June 1, 2002
Summary
This consensus review highlights the critical role of blood pressure (BP) monitoring in research, advocating for advanced non-invasive techniques and complementary use of automated ambulatory BP monitoring (ABPM) and self BP measurements (SBPM). Technological advancements, including telemedicine, are poised to further enhance BP monitoring capabilities in clinical trials and pharmacological studies.
Area of Science:
- Cardiovascular Research
- Hypertension Studies
- Clinical Trial Methodologies
Background:
- Consensus conference convened to discuss blood pressure (BP) monitoring techniques in diverse research settings.
- Key issues and advancements in pathophysiological, clinical outcome, and clinical pharmacology trials were addressed.
Framework:
- Acknowledged the essential role of continuous BP monitoring in pathophysiological studies, advocating for non-invasive beat-by-beat techniques.
- Highlighted that automated ambulatory BP monitoring (ABPM) and self BP measurements (SBPM) offer complementary advantages in clinical trials, not alternative solutions.
- Discussed the established routine use of ABPM in clinical pharmacology for evaluating 24-hour drug effects.
Implementation:
- Explored specific models for analyzing BP fluctuations, including chronobiological approaches and limitations like data over-modelling.
- Addressed the potential circaseptan rhythm in BP and practical challenges of repeated 24-hour ABPM.
- Considered the integration of telemonitoring systems for home SBPM and its clinical applications.
Implications:
- Emphasized the need for further technological development in non-invasive BP monitoring.
- Stressed the complementary roles of ABPM and SBPM in advancing hypertension research and treatment trials.
- Indicated the future potential of telemedicine in remote BP monitoring for hypertension management.