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[TT (TTV) Virus]
1Research and Production Center Diagnostic Systems, State Medical Academy, Nizhny Novgorod, Russia.
Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
|June 5, 2002
Summary
This review updates TT virus (TTV) diagnostics using PCR, detailing its discovery, taxonomy, and prevalence. It addresses viral variability challenges and discusses TTV
Area of Science:
- Virology
- Molecular Biology
- Infectious Diseases
Context:
- TT virus (TTV) is a non-enveloped, single-stranded DNA virus belonging to the Anelloviridae family.
- TTV infection is widespread globally, with varying prevalence rates across different populations.
- Understanding TTV's characteristics is crucial for accurate diagnosis and assessing its clinical significance.
Purpose:
- To provide an updated review on the characterization, diagnostics, and pathogenetic importance of TT virus (TTV).
- To highlight the challenges in TTV detection due to viral variability and guide the selection of appropriate DNA fragments for PCR.
- To consolidate current knowledge on TTV prevalence, replication, persistence, and pathogenetic concepts.
Summary:
- This review details the discovery, taxonomy, and identification of TT virus (TTV), emphasizing advancements in PCR-based diagnostics.
- It addresses the complexities of TTV DNA fragment selection for amplification owing to viral variability.
- Current data on TTV prevalence, replication, persistence, and pathogenetic concepts are presented and discussed.
Impact:
- Improved understanding of TTV diagnostics and challenges, aiding researchers and clinicians in accurate TTV infection detection.
- Provides a foundation for further research into TTV's role in human health and disease.
- Contributes to the global knowledge base on Anelloviridae, facilitating comparative virology studies.