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The CTLA4 +49 A/G dimorphism is not associated with type 1 diabetes in Czech children
O Cinek1, P Drevínek, Z Sumník
12nd Department of Paediatrics, 2nd Medical School, Charles University, Prague, Czech Republic. Ondrej.Cinek@Lfmotol.cuni.cz
Abstract:
We investigated the association of the CTLA4 +49 A/G dimorphism with type 1 diabetes in Czech children. Genotyping of 305 diabetic children and 289 controls by a novel PCR-ARMS assay revealed no significant differences in the genotypic or allelic frequencies. This may be another piece of evidence against the +49 A/G transition as the aetiological polymorphism within the CTLA4 gene.