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[Clinical evolution of a cohort of patients with Graves-Basedow disease treated with metimazole]
Daniel Antonio De Luis1, Ana Arconada, Rocío Aller
1Sección de Endocrinología y Nutrición Clínica, Hospital del Río Hortega, Valladolid, Instituto de Endocrinología y Nutrición Clínica, Facultad de Medicina de Valladolid, Spain.
Background:
Prospective studies of Graves-Basedow disease in Spain are scarce. Our objective was to evaluate the clinical and biochemical evolution of a cohort of patients with Graves-Basedow disease.
Patients And Method:
202 patients with Graves-Basedow disease diagnosed between January 1997 and June 1999.
Results:
5.9% of patients received 131I and 2.5% underwent surgery after treatment with methimazole. A relapse was observed in 23.3% patients. In the survival analysis, significant differences with regard to the rate of relapse were observed according to the goitre degree.
Conclusions:
In our study, all patients reached remission with methimazole. There was a high rate of relapse following discontinuation of therapy within the first months. Goitre size at the time of diagnosis was a significant determining factor of relapse.
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