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Developmental expression pattern of oncostatin M receptor beta in mice
Shinobu Tamura1, Yoshihiro Morikawa, Minoru Tanaka
1Department of Anatomy and Neurobiology, Wakayama Medical University, 811-1 Kimiidera, 641-0012 Wakayama, Japan.
Mechanisms of Development
|June 7, 2002
Summary
Oncostatin M receptor beta (OSMRbeta) expression was mapped in mice. OSMRbeta is found in early embryonic tissues and later in various organs, suggesting broad roles in development.
Area of Science:
- Developmental Biology
- Immunology
- Molecular Biology
Background:
- Oncostatin M (OSM) is an interleukin-6 family cytokine involved in hematopoiesis and liver development.
- The Oncostatin M receptor beta (OSMRbeta) subunit was recently identified in aorta-gonad-mesonephros (AGM) region-derived LO cells.
Purpose of the Study:
- To investigate the expression pattern of OSMRbeta during murine embryogenesis, postnatal development, and in adult tissues.
- To elucidate the spatiotemporal distribution of OSMRbeta gene expression.
Main Methods:
- In situ hybridization was employed to detect OSMRbeta gene expression.
- Analysis was performed across different developmental stages: embryonic (11.5 and 14.5 days postcoitum), postnatal, and adult tissues.
Main Results:
- OSMRbeta expression was first detected at 11.5 days postcoitum in the aortic endothelial cells of the AGM region.
- By 14.5 days postcoitum, OSMRbeta was observed in the primordia of the liver, thymus, choroid plexus, and limb.
- Postnatal and adult tissues showed detectable OSMRbeta expression in lymph nodes, bone, heart, kidney, small intestine, nasal cavity, and lung.
Conclusions:
- OSMRbeta exhibits dynamic spatiotemporal expression patterns throughout murine development.
- The widespread expression of OSMRbeta suggests its involvement in the development and function of multiple organ systems beyond hematopoiesis and liver development.