[Interferon therapy and immunotherapy in children with respiratory papillomatosis]

The ENT clinic of St-Petersburg Pediatric Medical Academy for 15 years admitted 126 children with respiratory papillomatosis 10 months to 15 years of age. 111 of them had laryngeal papillomatosis. The scheme of combined treatment was adjusted to interferon status of the patients. Replacement therapy with recombinant interferon--viferon--was applied in low production of alpha/beta-interferon but high serum interferon. In low serum interferon and intact interferon reserves the treatment was combined: interferon inductor--cycloferon plus viferon. In all the children the above treatment was given following surgical (microendoscopic) removal of laryngeal papillomas. The clinical course of laryngeal papillomatosis ran in accordance with changes of interferon status in the majority of cases.