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Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
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Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

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[NOTHROMBEL EFFECT ON THE EXPRESSION OF MEMBRANE COMPLEX GPIb-IX-V PLATELETS ACTIVATED BY THROMBIN]

O S Veselkina, N N Petrishchev, L V Vasina

    Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova
    |September 8, 2018
    PubMed
    Summary

    Nothrombel effectively reduces thrombin-induced platelet activation by inhibiting the expression of the GPIb-IX-V complex. This compound shows significant inhibitory activity against GPIb and GPIX, suggesting potential therapeutic applications in platelet disorders.

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