Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Heart development: learning from mistakes.

David G McFadden1, Eric N Olson

  • 1Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, Texas 75390-9148, USA.

Current Opinion in Genetics & Development
|June 22, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Loss of heterozygosity exposes germline mutations in complex I and drives Warburg metabolism in oncocytic carcinoma of the thyroid.

Science advances·2026
Same author

Loss of heterozygosity exposes germline mutations in complex I and drives Warburg metabolism in oncocytic carcinoma of the thyroid.

bioRxiv : the preprint server for biology·2025
Same author

Gene Editing Applications as Future Cardiovascular Therapies.

Annual review of genetics·2025
Same author

Cellular Reprogramming by PHF7 Enhances Cardiac Function Following Myocardial Infarction.

Circulation·2025
Same author

A mechanistic basis of fast myofiber vulnerability to neuromuscular diseases.

Cell reports·2025
Same author

Optimized genomic editing of a common Duchenne muscular dystrophy mutation in patient-derived muscle cells and a new humanized mouse model.

Molecular therapy. Nucleic acids·2025
Same journal

Temporal trajectories underlying adult neuronal diversity.

Current opinion in genetics & development·2026
Same journal

Transcription regulation of cell fate plasticity - from embryonic development to tissue regeneration.

Current opinion in genetics & development·2026
Same journal

Shared molecular and cellular programs during regeneration of glandular epithelia.

Current opinion in genetics & development·2026
Same journal

Lineage tracing in human cortical development.

Current opinion in genetics & development·2026
Same journal

Cis-regulatory strategies in developmental patterning.

Current opinion in genetics & development·2026
Same journal

GABAergic neuron fate specification and lineage allocation: from development to disorder.

Current opinion in genetics & development·2026
See all related articles

Understanding congenital heart disease (CHD) requires studying embryonic development. Research in animal models and human genetics reveals key molecular players in heart formation, aiding CHD research.

Area of Science:

  • Developmental Biology
  • Genetics
  • Cardiovascular Research

Background:

  • Congenital heart disease (CHD) arises from errors in embryonic cardiovascular system development.
  • Genetic and molecular factors significantly influence heart formation.
  • Studying animal models has been crucial for understanding heart development.

Purpose of the Study:

  • To identify key signaling molecules and transcriptional regulators involved in heart formation.
  • To understand the genetic basis of familial congenital heart disease.
  • To establish a molecular framework for vertebrate heart development.

Main Methods:

  • Characterization of mutations in cardiovascular development using diverse animal models (e.g., flies, mice).
  • Analysis of human pedigrees with familial forms of CHD.

Related Experiment Videos

  • Integration of data from animal models and human genetic studies.

    • Main Results:

    • Identification of numerous critical signaling molecules and transcriptional regulators in heart formation.
    • Demonstration that mutations in these molecules are linked to familial human CHD.
    • Emerging molecular framework for vertebrate heart development.

    Conclusions:

    • Abnormal embryonic cardiovascular morphogenesis causes human CHD.
    • A combination of animal model studies and human genetic analysis is elucidating the molecular control of heart formation.
    • This research provides insights into the genetic underpinnings of congenital heart defects.