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[Reversible aggregation of erythrocytes in children with appendicular peritonitis]
Insights
Reversible erythrocyte aggregation intensifies with appendicular peritonitis in children. This finding aids in diagnosing and predicting the condition, guiding treatment strategies and surgical planning.
Area of Science:
- Hematology
- Pediatric Surgery
- Clinical Diagnostics
Context:
- Appendicular peritonitis is a common surgical emergency in children.
- Accurate diagnosis and prognosis are crucial for effective management.
- Erythrocyte aggregation kinetics offer a potential biomarker.
Purpose:
- To quantitatively evaluate reversible erythrocyte aggregation in pediatric appendicular peritonitis.
- To assess the diagnostic and prognostic significance of erythrocyte aggregation.
- To explore the utility of this microtest in guiding treatment decisions.
Summary:
- A microtest measuring reversible erythrocyte aggregation was applied to 47 patients and 203 children (ages 3-15) with appendicular peritonitis.
- Increased reversible erythrocyte aggregation was observed in patients with both local and diffuse peritonitis.
- Diagnosis was confirmed clinically, intraoperatively, and pathologically.
Impact:
- Pronounced erythrocyte aggregation intensification correlates with appendicular peritonitis severity.
- This finding highlights the diagnostic and prognostic value of reversible erythrocyte aggregation.
- The microtest can inform preoperative treatment strategies and surgical intervention planning.
Abstract:
A microtest for quantitative evaluation of the kinetics of reversible aggregation of erythrocytes was used in 47 patients and 203 children with local (121 cases) and diffuse (82 cases) appendicular peritonitis. The patients' ages varied from 3 to 15 years. The diagnosis was confirmed clinically, intraoperatively, and morphologically during examination of removed appendices. The development of appendicular peritonitis of different dissemination was paralleled by pronounced intensification of reversible aggregation of peripheral blood erythrocytes, which suggests high diagnostic and prognostic significance of reversible aggregation of erythrocytes, determines the strategy of preoperative treatment, and helps plan the volume of intervention.