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Children with ADHD and motor dysfunction compared with children with ADHD only.

Raymond C Tervo1, Scott Azuma, Bruce Fogas

  • 1Department of Pediatrics, University of Minnesota, Minneapolis, USA. rtervo@gillettechildrens.com

Developmental Medicine and Child Neurology
|June 29, 2002
PubMed
Summary

Children with ADHD and motor dysfunction (ADHD-MD) showed similar medication responses to those with ADHD alone. Methylphenidate effectively treated both groups, indicating no significant difference in treatment outcomes.

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Area of Science:

  • Child and Adolescent Psychiatry
  • Neurodevelopmental Disorders
  • Pharmacology

Background:

  • Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder.
  • Motor dysfunction (MD) frequently co-occurs with ADHD, potentially impacting treatment.
  • Understanding group differences and medication response in ADHD with and without MD is crucial.

Purpose of the Study:

  • To identify differences between children with ADHD and motor dysfunction (ADHD-MD) and ADHD only.
  • To evaluate the medication responsiveness of ADHD-MD to methylphenidate.
  • To compare treatment effects of methylphenidate in children with ADHD-MD versus ADHD only.

Main Methods:

  • A triple-blind, placebo-controlled crossover study involving 63 children with ADHD.

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  • Children received methylphenidate (0.3 mg/kg and 0.5 mg/kg) or placebo twice daily.
  • Behavior and functioning were assessed at home and school using validated questionnaires.

    • Main Results:

    • Children with ADHD-MD were more likely to present with severe ADHD-combined type and other neurodevelopmental issues.
    • Both groups exhibited a linear dose-response relationship to methylphenidate.
    • No significant group-by-dose interaction or overall group effect on behavior/functioning was observed.

    Conclusions:

    • Children with ADHD-MD and ADHD only demonstrate similar responses to methylphenidate.
    • Methylphenidate effectively treats ADHD symptoms in both groups, suggesting comparable medication efficacy.
    • Motor dysfunction does not appear to alter the overall medication response in children with ADHD.