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Related Experiment Videos

Cardiovascular autonomic function in systemic lupus erythematosus.

M B Hogarth1, L Judd, C J Mathias

  • 1Rheumatology Unit, Imperial College School of Medicine, St Mary's Hospital, London, UK. m.b.hogarth@btinternet.com

Lupus
|July 2, 2002
PubMed
Summary
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Cardiovascular autonomic function may be impaired in patients with systemic lupus erythematosus (SLE). Many SLE patients experience symptoms linked to autonomic dysfunction, suggesting a need for assessment.

Area of Science:

  • Immunology
  • Cardiology
  • Neurology

Background:

  • Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with potential multi-organ involvement.
  • Cardiovascular complications are a significant concern in SLE patients.
  • Autonomic nervous system dysfunction has been anecdotally reported in SLE.

Purpose of the Study:

  • To investigate whether cardiovascular autonomic function is impaired in individuals diagnosed with SLE.
  • To compare autonomic function between SLE patients and a healthy control group.

Main Methods:

  • A case-control study involving 23 patients with SLE and a control group.
  • Assessment of autonomic symptoms via a standardized questionnaire.
  • Measurement of cardiovascular autonomic function using 10 non-invasive tests.

Related Experiment Videos

  • Analysis of plasma adrenaline and noradrenaline levels.

    • Main Results:

    • Significant differences in cardiovascular autonomic function were observed between SLE patients and controls in three out of 24 tested parameters.
    • Specifically, reduced systolic blood pressure during head-up tilt and altered heart rate responses to isometric exercise and cold pressor tests were noted in SLE patients.
    • Eleven SLE patients (48%) exhibited abnormal heart rate, blood pressure, or Valsalva responses, compared to six controls.
    • Plasma catecholamine levels (adrenaline and noradrenaline) were significantly lower in SLE patients.
    • Twenty-one SLE patients (91%) reported symptoms potentially related to autonomic dysfunction, though symptom count did not correlate with objective autonomic impairment.

    Conclusions:

    • Cardiovascular autonomic impairment can be demonstrated in a subset of patients with SLE.
    • Symptoms suggestive of autonomic dysfunction are prevalent in SLE.
    • Routine autonomic function assessment may be warranted for SLE patients to identify potential impairment.