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[Neurogenic inflammation. II. pathophysiology and clinical implications].

M K Herbert1, P Holzer

  • 1Klinik für Anaesthesiologie, Universität Würzburg. mherbert@anaesthesie.uni-wuerzburg.de

Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS
|July 9, 2002
PubMed
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Neurogenic inflammation, triggered by sensory neurons releasing neuropeptides, causes tissue responses like redness and swelling. Its role in human diseases is debated due to conflicting clinical trial results.

Area of Science:

  • Neuroscience
  • Immunology
  • Pathophysiology

Context:

  • Neurogenic inflammation involves sensory neuron activation and neuropeptide release (e.g., substance P, CGRP).
  • This process leads to tissue responses including hyperaemia, oedema, and potentially pain.
  • It is implicated in various human diseases, including chronic pain syndromes like migraine and arthritis.

Purpose:

  • To critically review the evidence for neurogenic inflammation's role in human diseases.
  • To discuss the discrepancy between rodent model findings and human clinical trial outcomes.
  • To explore the dual role of neurogenic inflammation in both inflammatory processes and protective tissue responses.

Summary:

  • Activation of unmyelinated sensory neurons by noxious stimuli releases neuropeptides, causing neurogenic inflammation characterized by hyperaemia and oedema.

Related Experiment Videos

  • While implicated in conditions like migraine and arthritis, the efficacy of substance P receptor antagonists in human trials challenges its direct role.
  • Neurogenic inflammation also functions as a protective mechanism, aiding tissue integrity and repair.

    • Impact:

    • Highlights the complex and debated role of neurogenic inflammation in human pathology.
    • Underscores the need for further research to reconcile findings across species and clinical settings.
    • Recognizes neurogenic inflammation's contribution to both disease pathogenesis and beneficial physiological responses.